About Semenogelin-2
Semenogelin-2 (SEMG2) is a protein
from Homo sapiens identified by UniProt accession
Q02383, 582 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Semenogelin-2 |
|---|
| UniProt accession | Q02383 |
|---|
| Gene | SEMG2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 582 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- elafin measurement · score 0.13
- blood protein measurement · score 0.13
- genetic disorder · score 0.12
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
- spermatogenic failure 3 · score 0.05
- spermatogenic failure 55 · score 0.05
- spermatogenic failure 7 · score 0.05
- spermatogenic failure 29 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02383-F1 | alphafold | PREDICTED | 30.72 | — |
Amino-acid sequence (582 residues)
MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG QKDQQHTKSK GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL GGSQQLLNYK QEGRDHDKSK GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP SGKGLSSQCS NTEKRLWVHG LSKEQASASG AQKGRTQGGS QSSYVLQTEE LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS SSTEERHLNC GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG HKENKISYQS SSTEERRLNS GEKDVQKGVS KGSISIQTEE KIHGKSQNQV TIPSQDQEHG HKENKMSYQS SSTEERRLNY GGKSTQKDVS QSSISFQIEK LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH EQKGRYKQES SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST
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