About Desmocollin-2
Desmocollin-2 (DSC2) is a protein
from Homo sapiens identified by UniProt accession
Q02487, 901 residues long.
MolForge cross-references it against 0 known binders and
199 disease associations.
Target properties
| Protein name | Desmocollin-2 |
|---|
| UniProt accession | Q02487 |
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| Gene | DSC2 |
|---|
| Organism | Homo sapiens |
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| Length | 901 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (199)
Diseases linked to this target (Open Targets).
- Arrhythmogenic right ventricular dysplasia · score 0.81
- familial isolated arrhythmogenic right ventricular dysplasia · score 0.74
- arrhythmogenic right ventricular cardiomyopathy · score 0.63
- Abnormality of the cardiovascular system · score 0.54
- neurodegenerative disease · score 0.49
- cardiomyopathy · score 0.39
- familial isolated arrhythmogenic ventricular dysplasia, left dominant form · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, biventricular form · score 0.37
- familial isolated arrhythmogenic ventricular dysplasia, right dominant form · score 0.37
- dilated cardiomyopathy 1A · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02487-F1 | alphafold | PREDICTED | 76.77 | — |
Amino-acid sequence (901 residues)
MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG RVNLKECFTA ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN TENQEKKKIF VFLEHQTKVL KKRHTKEKVL RRAKRRWAPI PCSMLENSLG PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ EPRNLFYVER DTGNLYCTRP VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY PIFTEETYTF TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND HLPTFTRTSY VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE NGNFKIVTDA KTNEGVLCVV KPLNYEEKQQ MILQIGVVNE APFSREASPR SAMSTATVTV NVEDQDEGPE CNPPIQTVRM KENAEVGTTS NGYKAYDPET RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI KNGIYNITVL ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYVVPI TVRDRLGMSS VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI LLGIALLFCI LFTLVCGASG TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV YSANGFTTQT VGASAQGVCG TVGSGIKNGG QETIEMVKGG HQTSESCRGA GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEKVYL CNQDENHKHA QDYVLTYNYE GRGSVAGSVG CCSERQEEDG LEFLDNLEPK FRTLAEACMK R
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