About Histone H1.1
Histone H1.1 (H1-1) is a protein
from Homo sapiens identified by UniProt accession
Q02539, 215 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Histone H1.1 |
|---|
| UniProt accession | Q02539 |
|---|
| Gene | H1-1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 215 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.24
- mean corpuscular hemoglobin concentration · score 0.22
- mean corpuscular volume · score 0.18
- mean reticulocyte volume · score 0.16
- lymphocyte count · score 0.13
- red blood cell density measurement · score 0.13
- liver iron measurement · score 0.11
- BMI-adjusted waist-hip ratio · score 0.10
- breast carcinoma · score 0.08
- blood protein measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02539-F1 | alphafold | PREDICTED | 64.46 | — |
Amino-acid sequence (215 residues)
MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA ASSSKERGGV SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK GTGASGSFKL NKKASSVETK PGASKVATKT KATGASKKLK KATGASKKSV KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV AKSPAKAKAV KPKAAKARVT KPKTAKPKKA APKKK
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