About Large ribosomal subunit protein eL20
Large ribosomal subunit protein eL20 (RPL18A) is a protein
from Homo sapiens identified by UniProt accession
Q02543, 176 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein eL20 |
|---|
| UniProt accession | Q02543 |
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| Gene | RPL18A |
|---|
| Organism | Homo sapiens |
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| Length | 176 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- Becker muscular dystrophy · score 0.29
- clear cell renal carcinoma · score 0.27
- endometrial cancer · score 0.27
- qualitative or quantitative defects of dystrophin · score 0.26
- aniridia · score 0.09
- diffuse large B-cell lymphoma · score 0.08
- epilepsy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02543-F1 | alphafold | PREDICTED | 96.32 | — |
Amino-acid sequence (176 residues)
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAASKCRRP AVKQFHDSKI KFPLPHRVLR RQHKPRFTTK RPNTFF
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