Paired box protein Pax-5 (PAX5)

About Paired box protein Pax-5

Paired box protein Pax-5 (PAX5) is a protein from Homo sapiens identified by UniProt accession Q02548, 391 residues long. MolForge cross-references it against 0 known binders and 556 disease associations.

Target properties

Protein name	Paired box protein Pax-5
UniProt accession	Q02548
Gene	PAX5
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (556)

Diseases linked to this target (Open Targets).

acute lymphoblastic leukemia · score 0.53
T-cell acute lymphoblastic leukemia · score 0.52
neurodegenerative disease · score 0.51
Neurodevelopmental disorder · score 0.49
unipolar depression · score 0.45
chronotype measurement · score 0.41
prostate adenocarcinoma · score 0.40
lymphoid neoplasm · score 0.37
lung carcinoma · score 0.37
hemangioblastoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02548-F1	alphafold	PREDICTED	63.23	—

Amino-acid sequence (391 residues)

MDLEKNYPTP RTSRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA EYKRQNPTMF AWEIRDRLLA ERVCDNDTVP SVSSINRIIR TKVQQPPNQP VPASSHSIVS TGSVTQVSSV STDSAGSSYS ISGILGITSP SADTNKRKRD EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV FERQHYSDIF TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LASPTPADIG SSVPGPQSYP IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ YSSYNDSWRF PNPGLLGSPY YYSAAARGAA PPAAATAYDR H

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards