Interferon regulatory factor 8 (IRF8)

About Interferon regulatory factor 8

Interferon regulatory factor 8 (IRF8) is a protein from Homo sapiens identified by UniProt accession Q02556, 426 residues long. MolForge cross-references it against 0 known binders and 664 disease associations.

Target properties

Protein name	Interferon regulatory factor 8
UniProt accession	Q02556
Gene	IRF8
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (664)

Diseases linked to this target (Open Targets).

monocyte count · score 0.65
monocyte percentage of leukocytes · score 0.65
neutrophil count · score 0.51
neutrophil percentage of leukocytes · score 0.51
leukocyte count · score 0.49
granulocyte percentage of myeloid white cells · score 0.48
chronic lymphocytic leukemia · score 0.47
eosinophil count · score 0.46
ulcerative colitis · score 0.45
rheumatoid arthritis · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02556-F1	alphafold	PREDICTED	74.70	—

Amino-acid sequence (426 residues)

MCDRNGGRRL RQWLIEQIDS SMYPGLIWEN EEKSMFRIPW KHAGKQDYNQ EVDASIFKAW AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDISEPYKVY RIVPEEEQKC KLGVATAGCV NEVTEMECGR SEIDELIKEP SVDDYMGMIK RSPSPPEACR SQLLPDWWAQ QPSTGVPLVT GYTTYDAHHS AFSQMVISFY YGGKLVGQAT TTCPEGCRLS LSQPGLPGTK LYGPEGLELV RFPPADAIPS ERQRQVTRKL FGHLERGVLL HSSRQGVFVK RLCQGRVFCS GNAVVCKGRP NKLERDEVVQ VFDTSQFFRE LQQFYNSQGR LPDGRVVLCF GEEFPDMAPL RSKLILVQIE QLYVRQLAEE AGKSCGAGSV MQAPEEPPPD QVFRMFPDIC ASHQRSFFRE NQQITV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards