About Helix-loop-helix protein 1
Helix-loop-helix protein 1 (NHLH1) is a protein
from Homo sapiens identified by UniProt accession
Q02575, 133 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Helix-loop-helix protein 1 |
|---|
| UniProt accession | Q02575 |
|---|
| Gene | NHLH1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 133 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (125)
Diseases linked to this target (Open Targets).
- myeloid white cell count · score 0.13
- Romano-Ward syndrome · score 0.08
- Arrhythmogenic right ventricular dysplasia · score 0.08
- Familial short QT syndrome · score 0.07
- Brugada syndrome · score 0.07
- familial atrial fibrillation · score 0.07
- hypertrophic cardiomyopathy · score 0.07
- Familial progressive cardiac conduction defect · score 0.07
- dilated cardiomyopathy · score 0.06
- cardiac conduction defect · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02575-F1 | alphafold | PREDICTED | 75.97 | — |
Amino-acid sequence (133 residues)
MMLNSDTMEL DLPPTHSETE SGFSDCGGGA GPDGAGPGGP GGGQARGPEP GEPGRKDLQH LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK LLPTLPPDKK LSKIEILRLA ICYISYLNHV LDV
Explore Helix-loop-helix protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets