About Helix-loop-helix protein 2
Helix-loop-helix protein 2 (NHLH2) is a protein
from Homo sapiens identified by UniProt accession
Q02577, 135 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Helix-loop-helix protein 2 |
|---|
| UniProt accession | Q02577 |
|---|
| Gene | NHLH2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 135 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (237)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism · score 0.42
- vesicoureteral reflux · score 0.27
- Kallmann syndrome · score 0.07
- Testicular regression syndrome · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.07
- ring chromosome Y · score 0.07
- 46,XY partial gonadal dysgenesis · score 0.06
- partial androgen insensitivity syndrome · score 0.06
- 46,XX gonadal dysgenesis · score 0.06
- Leydig cell hypoplasia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02577-F1 | alphafold | PREDICTED | 75.79 | — |
Amino-acid sequence (135 residues)
MMLSPDQAAD SDHPSSAHSD PESLGGTDTK VLGSVSDLEP VEEAEGDGKG GSRAALYPHP QQLSREEKRR RRRATAKYRS AHATRERIRV EAFNLAFAEL RKLLPTLPPD KKLSKIEILR LAICYISYLN HVLDV
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