About Voltage-dependent L-type calcium channel subunit beta-1
Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) is a protein
from Homo sapiens identified by UniProt accession
Q02641, 598 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Voltage-dependent L-type calcium channel subunit beta-1 |
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| UniProt accession | Q02641 |
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| Gene | CACNB1 |
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| Organism | Homo sapiens |
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| Length | 598 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (61)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.46
- generalized anxiety disorder · score 0.39
- Polyuria · score 0.37
- Urinary incontinence · score 0.37
- gastrointestinal disease · score 0.37
- anxiety · score 0.27
- mathematical ability · score 0.27
- self reported educational attainment · score 0.27
- breast adenocarcinoma · score 0.26
- neurodegenerative disease · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02641-F1 | alphafold | PREDICTED | 69.03 | — |
Amino-acid sequence (598 residues)
MVQKTSMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR LGSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP NPLLNRTMAT AALAASPAPV SNLQGPYLAS GDQPLERATG EHASMHEYPG ELGQPPGLYP SSHPPGRAGT LRALSRQDTF DADTPGSRNS AYTELGDSCV DMETDPSEGP GLGDPAGGGT PPARQGSWED EEEDYEEELT DNRNRGRNKA RYCAEGGGPV LGRNKNELEG WGRGVYIR
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