About Growth hormone-releasing hormone receptor
Growth hormone-releasing hormone receptor (GHRHR) is a protein
from Homo sapiens identified by UniProt accession
Q02643, 423 residues long.
MolForge cross-references it against 0 known binders and
253 disease associations.
Target properties
| Protein name | Growth hormone-releasing hormone receptor |
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| UniProt accession | Q02643 |
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| Gene | GHRHR |
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| Organism | Homo sapiens |
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| Length | 423 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (253)
Diseases linked to this target (Open Targets).
- isolated growth hormone deficiency type IB · score 0.65
- IGF-1 measurement · score 0.61
- HIV-Associated Lipodystrophy Syndrome · score 0.51
- body height · score 0.41
- neurodegenerative disease · score 0.33
- adolescent idiopathic scoliosis · score 0.31
- insulin like growth factor measurement · score 0.30
- genetic disorder · score 0.19
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02643-F1 | alphafold | PREDICTED | 75.82 | — |
Amino-acid sequence (423 residues)
MDRRMWGAHV FCVLSPLPTV LGHMHPECDF ITQLREDESA CLQAAEEMPN TTLGCPATWD GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG WSEPFPPYPV ACPVPLELLA EEESYFSTVK IIYTVGHSIS IVALFVAITI LVALRRLHCP RNYVHTQLFT TFILKAGAVF LKDAALFHSD DTDHCSFSTV LCKVSVAASH FATMTNFSWL LAEAVYLNCL LASTSPSSRR AFWWLVLAGW GLPVLFTGTW VSCKLAFEDI ACWDLDDTSP YWWIIKGPIV LSVGVNFGLF LNIIRILVRK LEPAQGSLHT QSQYWRLSKS TLFLIPLFGI HYIIFNFLPD NAGLGIRLPL ELGLGSFQGF IVAILYCFLN QEVRTEISRK WHGHDPELLP AWRTRAKWTT PSRSAAKVLT SMC
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