About Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) is a protein
from Homo sapiens identified by UniProt accession
Q02742, 428 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
|---|
| UniProt accession | Q02742 |
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| Gene | GCNT1 |
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| Organism | Homo sapiens |
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| Length | 428 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.41
- monocyte percentage of leukocytes · score 0.32
- P-selectin glycoprotein ligand 1 measurement · score 0.25
- D dimer measurement · score 0.23
- gut microbiome measurement · score 0.21
- glioblastoma multiforme · score 0.13
- glucuronate measurement · score 0.13
- infection · score 0.08
- infect · score 0.08
- metabolite measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02742-F1 | alphafold | PREDICTED | 93.28 | — |
Amino-acid sequence (428 residues)
MLRTLLRRRL FSYPTKYYFM VLVLSLITFS VLRIHQKPEF VSVRHLELAG ENPSSDINCT KVLQGDVNEI QKVKLEILTV KFKKRPRWTP DDYINMTSDC SSFIKRRKYI VEPLSKEEAE FPIAYSIVVH HKIEMLDRLL RAIYMPQNFY CIHVDTKSED SYLAAVMGIA SCFSNVFVAS RLESVVYASW SRVQADLNCM KDLYAMSANW KYLINLCGMD FPIKTNLEIV RKLKLLMGEN NLETERMPSH KEERWKKRYE VVNGKLTNTG TVKMLPPLET PLFSGSAYFV VSREYVGYVL QNEKIQKLME WAQDTYSPDE YLWATIQRIP EVPGSLPASH KYDLSDMQAV ARFVKWQYFE GDVSKGAPYP PCDGVHVRSV CIFGAGDLNW MLRKHHLFAN KFDVDVDLFA IQCLDEHLRH KALETLKH
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