Guanylin (GUCA2A)

About Guanylin

Guanylin (GUCA2A) is a protein from Homo sapiens identified by UniProt accession Q02747, 115 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Guanylin
UniProt accession	Q02747
Gene	GUCA2A
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.18
apolipoprotein A 1 measurement · score 0.10
systolic blood pressure · score 0.09
age at menarche · score 0.07
inflammatory bowel disease · score 0.06
colitis · score 0.06
Barrett's esophagus · score 0.06
colorectal cancer · score 0.05
neoplasm · score 0.04
ulcerative colitis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02747-F1	alphafold	PREDICTED	79.10	—

Amino-acid sequence (115 residues)

MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV GKLRNFAPIP GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED PGTCEICAYA ACTGC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards