About Dual specificity mitogen-activated protein kinase kinase 1
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) is a protein
from Homo sapiens identified by UniProt accession
Q02750, 393 residues long.
MolForge cross-references it against 0 known binders and
667 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 1 |
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| UniProt accession | Q02750 |
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| Gene | MAP2K1 |
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| Organism | Homo sapiens |
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| Length | 393 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (667)
Diseases linked to this target (Open Targets).
- cardiofaciocutaneous syndrome · score 0.84
- melanoma · score 0.78
- melorheostosis · score 0.73
- cancer · score 0.70
- neoplasm · score 0.68
- Noonan syndrome · score 0.66
- non-small cell lung carcinoma · score 0.61
- rasopathy · score 0.59
- cutaneous melanoma · score 0.55
- metastatic melanoma · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02750-F1 | alphafold | PREDICTED | 83.22 | — |
Amino-acid sequence (393 residues)
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV
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