About Peptidyl-prolyl cis-trans isomerase FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) is a protein
from Homo sapiens identified by UniProt accession
Q02790, 459 residues long.
MolForge cross-references it against 0 known binders and
348 disease associations.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase FKBP4 |
|---|
| UniProt accession | Q02790 |
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| Gene | FKBP4 |
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| Organism | Homo sapiens |
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| Length | 459 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (348)
Diseases linked to this target (Open Targets).
- testosterone measurement · score 0.52
- sex hormone-binding globulin measurement · score 0.45
- vital capacity · score 0.41
- BMI-adjusted waist-hip ratio · score 0.41
- hematocrit · score 0.40
- BMI-adjusted hip circumference · score 0.38
- apolipoprotein A 1 measurement · score 0.38
- estradiol measurement · score 0.38
- forced expiratory volume · score 0.30
- high density lipoprotein cholesterol measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02790-F1 | alphafold | PREDICTED | 90.38 | — |
Amino-acid sequence (459 residues)
MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA
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