About Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) is a protein
from Homo sapiens identified by UniProt accession
Q02809, 727 residues long.
MolForge cross-references it against 0 known binders and
971 disease associations.
Target properties
| Protein name | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 |
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| UniProt accession | Q02809 |
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| Gene | PLOD1 |
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| Organism | Homo sapiens |
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| Length | 727 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (971)
Diseases linked to this target (Open Targets).
- Ehlers-Danlos syndrome, kyphoscoliotic type 1 · score 0.82
- Ehlers-Danlos syndrome, kyphoscoliotic type · score 0.76
- Ehlers-Danlos syndrome, musculocontractural type · score 0.57
- familial thoracic aortic aneurysm and aortic dissection · score 0.54
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.53
- Ehlers-Danlos syndrome · score 0.51
- kyphoscoliotic Ehlers-Danlos syndrome · score 0.46
- Joint hypermobility · score 0.43
- neurodegenerative disease · score 0.41
- cryptorchidism · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02809-F1 | alphafold | PREDICTED | 92.73 | — |
Amino-acid sequence (727 residues)
MRPLLLLALL GWLLLAEAKG DAKPEDNLLV LTVATKETEG FRRFKRSAQF FNYKIQALGL GEDWNVEKGT SAGGGQKVRL LKKALEKHAD KEDLVILFAD SYDVLFASGP RELLKKFRQA RSQVVFSAEE LIYPDRRLET KYPVVSDGKR FLGSGGFIGY APNLSKLVAE WEGQDSDSDQ LFYTKIFLDP EKREQINITL DHRCRIFQNL DGALDEVVLK FEMGHVRARN LAYDTLPVLI HGNGPTKLQL NYLGNYIPRF WTFETGCTVC DEGLRSLKGI GDEALPTVLV GVFIEQPTPF VSLFFQRLLR LHYPQKHMRL FIHNHEQHHK AQVEEFLAQH GSEYQSVKLV GPEVRMANAD ARNMGADLCR QDRSCTYYFS VDADVALTEP NSLRLLIQQN KNVIAPLMTR HGRLWSNFWG ALSADGYYAR SEDYVDIVQG RRVGVWNVPY ISNIYLIKGS ALRGELQSSD LFHHSKLDPD MAFCANIRQQ DVFMFLTNRH TLGHLLSLDS YRTTHLHNDL WEVFSNPEDW KEKYIHQNYT KALAGKLVET PCPDVYWFPI FTEVACDELV EEMEHFGQWS LGNNKDNRIQ GGYENVPTID IHMNQIGFER EWHKFLLEYI APMTEKLYPG YYTRAQFDLA FVVRYKPDEQ PSLMPHHDAS TFTINIALNR VGVDYEGGGC RFLRYNCSIR APRKGWTLMH PGRLTHYHEG LPTTRGTRYI AVSFVDP
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