Large ribosomal subunit protein eL6 (RPL6)

About Large ribosomal subunit protein eL6

Large ribosomal subunit protein eL6 (RPL6) is a protein from Homo sapiens identified by UniProt accession Q02878, 288 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.

Target properties

Protein name	Large ribosomal subunit protein eL6
UniProt accession	Q02878
Gene	RPL6
Organism	Homo sapiens
Length	288 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (99)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Becker muscular dystrophy · score 0.29
qualitative or quantitative defects of dystrophin · score 0.26
acute myeloid leukemia · score 0.22
alkaline phosphatase measurement · score 0.21
Noonan syndrome · score 0.17
metachondromatosis · score 0.16
Noonan syndrome with multiple lentigines · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02878-F1	alphafold	PREDICTED	82.82	—

Amino-acid sequence (288 residues)

MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards