About Cyclic AMP-responsive element-binding protein 5
Cyclic AMP-responsive element-binding protein 5 (CREB5) is a protein
from Homo sapiens identified by UniProt accession
Q02930, 508 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Cyclic AMP-responsive element-binding protein 5 |
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| UniProt accession | Q02930 |
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| Gene | CREB5 |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (185)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.44
- heel bone mineral density · score 0.44
- schizophrenia · score 0.43
- monocyte count · score 0.43
- atrial fibrillation · score 0.42
- neutrophil count · score 0.42
- basophil count · score 0.41
- TPE interval measurement · score 0.40
- breast carcinoma · score 0.39
- pulse pressure measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02930-F1 | alphafold | PREDICTED | 57.08 | — |
Amino-acid sequence (508 residues)
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK TDNMLSDQTP TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS MHNAVGGAMT GPGTHQLSSA RLPNHDTNVV IQQAMPSPQS SSVITQAPST NRQIGPVPGS LSSLLHLHNR QRQPMPASMP GTLPNPTMPG SSAVLMPMER QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL THHPAAMSNG NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM QPTQTIQPPQ PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV MSLEKKAEEL TQTNMQLQNE VSMLKNEVAQ LKQLLLTHKD CPITAMQKES QGYLSPESSP PASPVPACSQ QQVIQHNTIT TSSSVSEVVG SSTLSQLTTH RTDLNPIL
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