Paired box protein Pax-2 (PAX2)

About Paired box protein Pax-2

Paired box protein Pax-2 (PAX2) is a protein from Homo sapiens identified by UniProt accession Q02962, 417 residues long. MolForge cross-references it against 0 known binders and 557 disease associations.

Target properties

Protein name	Paired box protein Pax-2
UniProt accession	Q02962
Gene	PAX2
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (557)

Diseases linked to this target (Open Targets).

renal coloboma syndrome · score 0.84
focal segmental glomerulosclerosis 7 · score 0.76
focal segmental glomerulosclerosis · score 0.74
neurodegenerative disease · score 0.49
heart rate response to recovery post exercise · score 0.46
systolic blood pressure · score 0.46
heart rate response to exercise · score 0.42
genetic disorder · score 0.41
diastolic blood pressure · score 0.40
familial idiopathic steroid-resistant nephrotic syndrome · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02962-F1	alphafold	PREDICTED	60.93	—

Amino-acid sequence (417 residues)

MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT PDGAGTGVTA PGHTIVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK RKRDEVEVYT DPAHIRGGGG LHLVWTLRDV SEGSVPNGDS QSGVDSLRKH LRADTFTQQQ LEALDRVFER PSYPDVFQAS EHIKSEQGNE YSLPALTPGL DEVKSSLSAS TNPELGSNVS GTQTYPVVTG RDMASTTLPG YPPHVPPTGQ GSYPTSTLAG MVPGSEFSGN PYSHPQYTAY NEAWRFSNPA LLSSPYYYSA APRGSAPAAA AAAYDRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards