Complement factor H-related protein 3 (CFHR3)

About Complement factor H-related protein 3

Complement factor H-related protein 3 (CFHR3) is a protein from Homo sapiens identified by UniProt accession Q02985, 330 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Complement factor H-related protein 3
UniProt accession	Q02985
Gene	CFHR3
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

age-related macular degeneration · score 0.46
atypical hemolytic-uremic syndrome · score 0.39
blood protein measurement · score 0.34
atypical hemolytic-uremic syndrome with I factor anomaly · score 0.34
total blood protein measurement · score 0.26
complement component C8 measurement · score 0.24
complement factor H measurement · score 0.23
complement factor H-related protein 1 measurement · score 0.22
IGA glomerulonephritis · score 0.22
coagulation factor measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02985-F1	alphafold	PREDICTED	91.74	—

Amino-acid sequence (330 residues)

MLLLINVILT LWVSCANGQV KPCDFPDIKH GGLFHENMRR PYFPVAVGKY YSYYCDEHFE TPSGSYWDYI HCTQNGWSPA VPCLRKCYFP YLENGYNQNY GRKFVQGNST EVACHPGYGL PKAQTTVTCT EKGWSPTPRC IRVRTCSKSD IEIENGFISE SSSIYILNKE IQYKCKPGYA TADGNSSGSI TCLQNGWSAQ PICINSSEKC GPPPPISNGD TTSFLLKVYV PQSRVEYQCQ PYYELQGSNY VTCSNGEWSE PPRCIHPCII TEENMNKNNI KLKGRSDRKY YAKTGDTIEF MCKLGYNANT SILSFQAVCR EGIVEYPRCE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards