About Hematopoietically-expressed homeobox protein HHEX
Hematopoietically-expressed homeobox protein HHEX (HHEX) is a protein
from Homo sapiens identified by UniProt accession
Q03014, 270 residues long.
MolForge cross-references it against 0 known binders and
248 disease associations.
Target properties
| Protein name | Hematopoietically-expressed homeobox protein HHEX |
|---|
| UniProt accession | Q03014 |
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| Gene | HHEX |
|---|
| Organism | Homo sapiens |
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| Length | 270 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (248)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- type 2 diabetes mellitus · score 0.49
- eosinophil count · score 0.46
- diabetes mellitus · score 0.44
- mean platelet volume · score 0.44
- birth weight · score 0.42
- Drugs used in diabetes use measurement · score 0.40
- body mass index · score 0.39
- inflammatory bowel disease · score 0.38
- eosinophil percentage of leukocytes · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03014-F1 | alphafold | PREDICTED | 65.05 | — |
Amino-acid sequence (270 residues)
MQYPHPGPAA GAVGVPLYAP TPLLQPAHPT PFYIEDILGR GPAAPTPAPT LPSPNSSFTS LVSPYRTPVY EPTPIHPAFS HHSAAALAAA YGPGGFGGPL YPFPRTVNDY THALLRHDPL GKPLLWSPFL QRPLHKRKGG QVRFSNDQTI ELEKKFETQK YLSPPERKRL AKMLQLSERQ VKTWFQNRRA KWRRLKQENP QSNKKEELES LDSSCDQRQD LPSEQNKGAS LDSSQCSPSP ASQEDLESEI SEDSDQEVDI EGDKSYFNAG
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