POU domain, class 3, transcription factor 1 (POU3F1)

About POU domain, class 3, transcription factor 1

POU domain, class 3, transcription factor 1 (POU3F1) is a protein from Homo sapiens identified by UniProt accession Q03052, 451 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	POU domain, class 3, transcription factor 1
UniProt accession	Q03052
Gene	POU3F1
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
rheumatoid arthritis · score 0.39
hypothyroidism · score 0.33
serum non-albumin protein measurement · score 0.28
thyroid disease · score 0.27
Thyroid preparation use measurement · score 0.26
bone density · score 0.26
urate measurement · score 0.26
smoking status measurement · score 0.25
age at menarche · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03052-F1	alphafold	PREDICTED	58.47	—

Amino-acid sequence (451 residues)

MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT GRADDGGGGG GFHARLVHQG AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG GGGASPPSAP PPPPPAALHH HHHHTLPGSV Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards