About cAMP-responsive element modulator
cAMP-responsive element modulator (CREM) is a protein
from Homo sapiens identified by UniProt accession
Q03060, 345 residues long.
MolForge cross-references it against 0 known binders and
229 disease associations.
Target properties
| Protein name | cAMP-responsive element modulator |
|---|
| UniProt accession | Q03060 |
|---|
| Gene | CREM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 345 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (229)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.43
- Crohn's disease · score 0.42
- neurodegenerative disease · score 0.34
- glioblastoma multiforme · score 0.31
- ulcerative colitis · score 0.27
- eosinophil percentage of leukocytes · score 0.25
- erythrocyte count · score 0.24
- inflammatory bowel disease · score 0.23
- hematocrit · score 0.23
- hemoglobin measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03060-F1 | alphafold | PREDICTED | 60.09 | — |
Amino-acid sequence (345 residues)
MTMETVESQH DGSITASLTE SKSAHVQTQT GQNSIPALAQ VSVAGSGTRR GSPAVTLVQL PSGQTIHVQG VIQTPQPWVI QSSEIHTVQV AAIAETDESA ESEGVIDSHK RREILSRRPS YRKILNELSS DVPGVPKIEE ERSEEEGTPP SIATMAVPTS IYQTSTGQYI AIAQGGTIQI SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ QFFVPGSQVV VQDEETELAP SHMAAATGDM PTYQIRAPTA ALPQGVVMAA SPGSLHSPQQ LAEEATRKRE LRLMKNREAA KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS PKTDY
Explore cAMP-responsive element modulator with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets