Protein ENL (MLLT1)

About Protein ENL

Protein ENL (MLLT1) is a protein from Homo sapiens identified by UniProt accession Q03111, 559 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	Protein ENL
UniProt accession	Q03111
Gene	MLLT1
Organism	Homo sapiens
Length	559 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
acute myeloid leukemia · score 0.39
acute lymphoblastic leukemia · score 0.38
B-cell acute lymphoblastic leukemia · score 0.37
lysosomal storage disease · score 0.35
T-cell acute lymphoblastic leukemia · score 0.28
blastic plasmacytoid dendritic cell neoplasm · score 0.28
body height · score 0.27
Global developmental delay · score 0.26
Hypertelorism · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03111-F1	alphafold	PREDICTED	64.66	—

Amino-acid sequence (559 residues)

MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VVFWLHDSFP KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE KLTFNNPTTE FRYKLLRAGG VMVMPEGADT VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG SKDANKESSK TSKPHKVTKE HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK EEKAPPPKAA FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA KKALEVEESN SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG PLRSMVEDLQ SEESDEDDSS SGEEAAGKTN PGRDSRLSFS DSESDNSADS SLPSREPPPP QKPPPPNSKV SGRRSPESCS KPEKILKKGT YDKAYTDELV ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF SLDETTVRKL QSCLEAVAT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards