About Guanine nucleotide-binding protein subunit alpha-12
Guanine nucleotide-binding protein subunit alpha-12 (GNA12) is a protein
from Homo sapiens identified by UniProt accession
Q03113, 381 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein subunit alpha-12 |
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| UniProt accession | Q03113 |
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| Gene | GNA12 |
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| Organism | Homo sapiens |
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| Length | 381 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (107)
Diseases linked to this target (Open Targets).
- body height · score 0.45
- BMI-adjusted hip circumference · score 0.42
- ulcerative colitis · score 0.42
- lean body mass · score 0.40
- platelet count · score 0.39
- BMI-adjusted waist circumference · score 0.39
- neuroimaging measurement · score 0.38
- white matter microstructure measurement · score 0.38
- neutrophil count · score 0.37
- leukocyte count · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03113-F1 | alphafold | PREDICTED | 89.40 | — |
Amino-acid sequence (381 residues)
MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE RRAVRRLVKI LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN ILKGSRVLVD ARDKLGIPWQ YSENEKHGMF LMAFENKAGL PVEPATFQLY VPALSALWRD SGIREAFSRR SEFQLGESVK YFLDNLDRIG QLNYFPSKQD ILLARKATKG IVEHDFVIKK IPFKMVDVGG QRSQRQKWFQ CFDGITSILF MVSSSEYDQV LMEDRRTNRL VESMNIFETI VNNKLFFNVS IILFLNKMDL LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR NRSKPLFHHF TTAIDTENVR FVFHAVKDTI LQENLKDIML Q
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