About Caveolin-1
Caveolin-1 (CAV1) is a protein
from Homo sapiens identified by UniProt accession
Q03135, 178 residues long.
MolForge cross-references it against 0 known binders and
1,088 disease associations.
Target properties
| Protein name | Caveolin-1 |
|---|
| UniProt accession | Q03135 |
|---|
| Gene | CAV1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 178 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1088)
Diseases linked to this target (Open Targets).
- pulmonary hypertension, primary, 3 · score 0.62
- congenital generalized lipodystrophy type 3 · score 0.58
- familial partial lipodystrophy · score 0.51
- atrial fibrillation · score 0.51
- electrocardiography · score 0.49
- PR interval · score 0.48
- reticulocyte count · score 0.47
- lymphocyte count · score 0.46
- heart rate response to recovery post exercise · score 0.46
- intraocular pressure measurement · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03135-F1 | alphafold | PREDICTED | 78.36 | — |
Amino-acid sequence (178 residues)
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTVCDPLF EAVGKIFSNV RINLQKEI
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