Aminoacylase-1 (ACY1)

About Aminoacylase-1

Aminoacylase-1 (ACY1) is a protein from Homo sapiens identified by UniProt accession Q03154, 408 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Aminoacylase-1
UniProt accession	Q03154
Gene	ACY1
Organism	Homo sapiens
Length	408 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (138)

Diseases linked to this target (Open Targets).

Aminoacylase 1 deficiency · score 0.77
Neurological conditions associated with aminoacylase 1 deficiency · score 0.69
Intellectual disability · score 0.47
IGF-1 measurement · score 0.43
genetic disorder · score 0.38
N-acetylmethionine measurement · score 0.37
toxic encephalopathy · score 0.37
inborn aminoacylase deficiency · score 0.27
neurodegenerative disease · score 0.22
body height · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03154-F1	alphafold	PREDICTED	96.41	—

Amino-acid sequence (408 residues)

MTSKGPEEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE TARQLGLGCQ KVEVAPGYVV TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK DSEGYIYARG AQDMKCVSIQ YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG GHQGMELFVQ RPEFHALRAG FALDEGIANP TDAFTVFYSE RSPWWVRVTS TGRPGHASRF MEDTAAEKLH KVVNSILAFR EKEWQRLQSN PHLKEGSVTS VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMNLTLEP EIMPAATDNR YIRAVGVPAL GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS VPALPSDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards