About Lamin-B2
Lamin-B2 (LMNB2) is a protein
from Homo sapiens identified by UniProt accession
Q03252, 620 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Lamin-B2 |
|---|
| UniProt accession | Q03252 |
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| Gene | LMNB2 |
|---|
| Organism | Homo sapiens |
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| Length | 620 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (112)
Diseases linked to this target (Open Targets).
- microcephaly 27, primary, autosomal dominant · score 0.65
- susceptibility to partial acquired lipodystrophy · score 0.55
- Progressive myoclonic epilepsy · score 0.54
- Primary microcephaly · score 0.37
- acquired partial lipodystrophy · score 0.28
- Neurodevelopmental disorder · score 0.15
- Generalized myoclonic seizure · score 0.11
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03252-F1 | alphafold | PREDICTED | 79.02 | — |
Amino-acid sequence (620 residues)
MSPPSPGRRR EQRRPRAAAT MATPLPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY IDRVRALELE NDRLLLKISE KEEVTTREVS GIKALYESEL ADARRVLDET ARERARLQIE IGKLRAELDE VNKSAKKREG ELTVAQGRVK DLESLFHRSE VELAAALSDK RGLESDVAEL RAQLAKAEDG HAVAKKQLEK ETLMRVDLEN RCQSLQEELD FRKSVFEEEV RETRRRHERR LVEVDSSRQQ EYDFKMAQAL EELRSQHDEQ VRLYKLELEQ TYQAKLDSAK LSSDQNDKAA SAAREELKEA RMRLESLSYQ LSGLQKQASA AEDRIRELEE AMAGERDKFR KMLDAKEQEM TEMRDVMQQQ LAEYQELLDV KLALDMEINA YRKLLEGEEE RLKLSPSPSS RVTVSRATSS SSGSLSATGR LGRSKRKRLE VEEPLGSGPS VLGTGTGGSG GFHLAQQASA SGSVSIEEID LEGKFVQLKN NSDKDQSLGN WRIKRQVLEG EEIAYKFTPK YILRAGQMVT VWAAGAGVAH SPPSTLVWKG QSSWGTGESF RTVLVNADGE EVAMRTVKKS SVMRENENGE EEEEEAEFGE EDLFHQQGDP RTTSRGCYVM
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