About 6-pyruvoyl tetrahydrobiopterin synthase
6-pyruvoyl tetrahydrobiopterin synthase (PTS) is a protein
from Homo sapiens identified by UniProt accession
Q03393, 145 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | 6-pyruvoyl tetrahydrobiopterin synthase |
|---|
| UniProt accession | Q03393 |
|---|
| Gene | PTS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 145 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (217)
Diseases linked to this target (Open Targets).
- 6-pyruvoyl-tetrahydropterin synthase deficiency · score 0.85
- BH4-deficient hyperphenylalaninemia A · score 0.85
- Hyperphenylalaninemia · score 0.84
- Intellectual disability · score 0.46
- Dystonia · score 0.42
- GTP cyclohydrolase I deficiency with hyperphenylalaninemia · score 0.41
- heel bone mineral density · score 0.35
- hyperphenylalaninemia due to tetrahydrobiopterin deficiency · score 0.34
- bone quantitative ultrasound measurement · score 0.24
- genetic disorder · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03393-F1 | alphafold | PREDICTED | 95.61 | — |
Amino-acid sequence (145 residues)
MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE
Explore 6-pyruvoyl tetrahydrobiopterin synthase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets