Rod outer segment membrane protein 1 (ROM1)

About Rod outer segment membrane protein 1

Rod outer segment membrane protein 1 (ROM1) is a protein from Homo sapiens identified by UniProt accession Q03395, 351 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.

Target properties

Protein name	Rod outer segment membrane protein 1
UniProt accession	Q03395
Gene	ROM1
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (126)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.60
Retinal dystrophy · score 0.33
vital capacity · score 0.24
triglyceride measurement · score 0.16
autosomal dominant retinitis pigmentosa · score 0.15
body fat percentage · score 0.13
forced expiratory volume · score 0.12
high density lipoprotein cholesterol measurement · score 0.12
Macular dystrophy · score 0.11
serum gamma-glutamyl transferase measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03395-F1	alphafold	PREDICTED	86.26	—

Amino-acid sequence (351 residues)

MAPVLPLVLP LQPRIRLAQG LWLLSWLLAL AGGVILLCSG HLLVQLRHLG TFLAPSCQFP VLPQAALAAG AVALGTGLVG VGASRASLNA ALYPPWRGVL GPLLVAGTAG GGGLLVVGLG LALALPGSLD EALEEGLVTA LAHYKDTEVP GHCQAKRLVD ELQLRYHCCG RHGYKDWFGV QWVSSRYLDP GDRDVADRIQ SNVEGLYLTD GVPFSCCNPH SPRPCLQNRL SDSYAHPLFD PRQPNQNLWA QGCHEVLLEH LQDLAGTLGS MLAVTFLLQA LVLLGLRYLQ TALEGLGGVI DAGGETQGYL FPSGLKDMLK TAWLQGGVAC RPAPEEAPPG EAPPKEDLSE A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards