Mevalonate kinase (MVK)

About Mevalonate kinase

Mevalonate kinase (MVK) is a protein from Homo sapiens identified by UniProt accession Q03426, 396 residues long. MolForge cross-references it against 0 known binders and 241 disease associations.

Target properties

Protein name	Mevalonate kinase
UniProt accession	Q03426
Gene	MVK
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (241)

Diseases linked to this target (Open Targets).

hyperimmunoglobulinemia D with periodic fever · score 0.85
mevalonic aciduria · score 0.84
disseminated superficial actinic porokeratosis · score 0.67
Vitamin B12-responsive methylmalonic acidemia type cblB · score 0.55
methylmalonic aciduria, cblB type · score 0.55
neurodegenerative disease · score 0.53
autoinflammatory syndrome · score 0.52
genetic disorder · score 0.47
retinitis pigmentosa · score 0.37
mevalonate kinase deficiency · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03426-F1	alphafold	PREDICTED	92.24	—

Amino-acid sequence (396 residues)

MLSEVLLVSA PGKVILHGEH AVVHGKVALA VSLNLRTFLR LQPHSNGKVD LSLPNIGIKR AWDVARLQSL DTSFLEQGDV TTPTSEQVEK LKEVAGLPDD CAVTERLAVL AFLYLYLSIC RKQRALPSLD IVVWSELPPG AGLGSSAAYS VCLAAALLTV CEEIPNPLKD GDCVNRWTKE DLELINKWAF QGERMIHGNP SGVDNAVSTW GGALRYHQGK ISSLKRSPAL QILLTNTKVP RNTRALVAGV RNRLLKFPEI VAPLLTSIDA ISLECERVLG EMGEAPAPEQ YLVLEELIDM NQHHLNALGV GHASLDQLCQ VTRARGLHSK LTGAGGGGCG ITLLKPGLEQ PEVEATKQAL TSCGFDCLET SIGAPGVSIH SATSLDSRVQ QALDGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards