About Parathyroid hormone/parathyroid hormone-related peptide receptor
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) is a protein
from Homo sapiens identified by UniProt accession
Q03431, 593 residues long.
MolForge cross-references it against 0 known binders and
288 disease associations.
Target properties
| Protein name | Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| UniProt accession | Q03431 |
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| Gene | PTH1R |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (288)
Diseases linked to this target (Open Targets).
- metaphyseal chondrodysplasia, Jansen type · score 0.79
- chondrodysplasia Blomstrand type · score 0.75
- primary failure of tooth eruption · score 0.75
- Eiken syndrome · score 0.70
- Blomstrand lethal chondrodysplasia · score 0.65
- osteoporosis · score 0.60
- postmenopausal osteoporosis · score 0.59
- bone fracture · score 0.57
- hypoparathyroidism · score 0.54
- Back pain · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03431-F1 | alphafold | PREDICTED | 70.95 | — |
Amino-acid sequence (593 residues)
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
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