About Antigen peptide transporter 1
Antigen peptide transporter 1 (TAP1) is a protein
from Homo sapiens identified by UniProt accession
Q03518, 748 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | Antigen peptide transporter 1 |
|---|
| UniProt accession | Q03518 |
|---|
| Gene | TAP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 748 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (131)
Diseases linked to this target (Open Targets).
- MHC class I deficiency · score 0.74
- Immunodeficiency by defective expression of HLA class 1 · score 0.66
- neuroinflammatory disorder · score 0.36
- neurodegenerative disease · score 0.24
- genetic disorder · score 0.19
- inflammatory bowel disease · score 0.16
- alpha-2-macroglobulin receptor-associated protein measurement · score 0.12
- IGA glomerulonephritis · score 0.08
- severe combined immunodeficiency due to IKK2 deficiency · score 0.07
- wellbeing measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03518-F1 | alphafold | PREDICTED | 78.48 | — |
Amino-acid sequence (748 residues)
MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI REGGTHQQLM EKKGCYWAMV QAPADAPE
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