Complement factor H-related protein 1 (CFHR1)

About Complement factor H-related protein 1

Complement factor H-related protein 1 (CFHR1) is a protein from Homo sapiens identified by UniProt accession Q03591, 330 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	Complement factor H-related protein 1
UniProt accession	Q03591
Gene	CFHR1
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

age-related macular degeneration · score 0.51
non-immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.46
blood protein measurement · score 0.41
atypical hemolytic-uremic syndrome · score 0.39
dense deposit disease · score 0.37
C3 glomerulonephritis · score 0.37
atypical hemolytic-uremic syndrome with I factor anomaly · score 0.34
serum alanine aminotransferase measurement · score 0.32
complement factor H-related protein 4 measurement · score 0.29
complement factor H-related protein 5 measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03591-F1	alphafold	PREDICTED	89.08	—

Amino-acid sequence (330 residues)

MWLLVSVILI SRISSVGGEA TFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV SPSKSFWTRI TCTEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC RSTDTSCVNP PTVQNAHILS RQMSKYPSGE RVRYECRSPY EMFGDEEVMC LNGNWTEPPQ CKDSTGKCGP PPPIDNGDIT SFPLSVYAPA SSVEYQCQNL YQLEGNKRIT CRNGQWSEPP KCLHPCVISR EIMENYNIAL RWTAKQKLYL RTGESAEFVC KRGYRLSSRS HTLRTTCWDG KLEYPTCAKR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards