About Collagen alpha-1(X) chain
Collagen alpha-1(X) chain (COL10A1) is a protein
from Homo sapiens identified by UniProt accession
Q03692, 680 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Collagen alpha-1(X) chain |
|---|
| UniProt accession | Q03692 |
|---|
| Gene | COL10A1 |
|---|
| Organism | Homo sapiens |
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| Length | 680 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (260)
Diseases linked to this target (Open Targets).
- Metaphyseal chondrodysplasia, Schmid type · score 0.83
- Schmid metaphyseal chondrodysplasia · score 0.78
- refractive error measurement · score 0.36
- refractive error · score 0.34
- Myopia · score 0.31
- age at onset · score 0.28
- age-related macular degeneration · score 0.26
- breast adenocarcinoma · score 0.25
- Abnormality of refraction · score 0.25
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03692-F1 | alphafold | PREDICTED | 57.49 | — |
Amino-acid sequence (680 residues)
MLPQIPFLLL VSLNLVHGVF YAERYQMPTG IKGPLPNTKT QFFIPYTIKS KGIAVRGEQG TPGPPGPAGP RGHPGPSGPP GKPGYGSPGL QGEPGLPGPP GPSAVGKPGV PGLPGKPGER GPYGPKGDVG PAGLPGPRGP PGPPGIPGPA GISVPGKPGQ QGPTGAPGPR GFPGEKGAPG VPGMNGQKGE MGYGAPGRPG ERGLPGPQGP TGPSGPPGVG KRGENGVPGQ PGIKGDRGFP GEMGPIGPPG PQGPPGERGP EGIGKPGAAG APGQPGIPGT KGLPGAPGIA GPPGPPGFGK PGLPGLKGER GPAGLPGGPG AKGEQGPAGL PGKPGLTGPP GNMGPQGPKG IPGSHGLPGP KGETGPAGPA GYPGAKGERG SPGSDGKPGY PGKPGLDGPK GNPGLPGPKG DPGVGGPPGL PGPVGPAGAK GMPGHNGEAG PRGAPGIPGT RGPIGPPGIP GFPGSKGDPG SPGPPGPAGI ATKGLNGPTG PPGPPGPRGH SGEPGLPGPP GPPGPPGQAV MPEGFIKAGQ RPSLSGTPLV SANQGVTGMP VSAFTVILSK AYPAIGTPIP FDKILYNRQQ HYDPRTGIFT CQIPGIYYFS YHVHVKGTHV WVGLYKNGTP VMYTYDEYTK GYLDQASGSA IIDLTENDQV WLQLPNAESN GLYSSEYVHS SFSGFLVAPM
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