About Voltage-gated potassium channel KCNC4
Voltage-gated potassium channel KCNC4 (KCNC4) is a protein
from Homo sapiens identified by UniProt accession
Q03721, 635 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Voltage-gated potassium channel KCNC4 |
|---|
| UniProt accession | Q03721 |
|---|
| Gene | KCNC4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 635 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- self reported educational attainment · score 0.41
- mathematical ability · score 0.40
- primary progressive multiple sclerosis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
- transverse myelitis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03721-F1 | alphafold | PREDICTED | 67.59 | — |
Amino-acid sequence (635 residues)
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY RSTLRTLPGT RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP GVFAYVLNYY RTGKLHCPAD VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ HRDAEEALDI FESPDGGGSG AGPSDEAGDD ERELALQRLG PHEGGAGHGA GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI TTFCLETHEA FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR FVRILRIFKL TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY YAERIGARPS DPRGNDHTDF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM LVGALCALAG VLTIAMPVPV IVNNFGMYYS LAMAKQKLPK KRKKHVPRPA QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS KQNGDANAVL SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA DGSVRKGTFV LRDLPLQHSP EAACPPTAGT LFLPH
Explore Voltage-gated potassium channel KCNC4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets