Homeobox even-skipped homolog protein 2 (EVX2)

About Homeobox even-skipped homolog protein 2

Homeobox even-skipped homolog protein 2 (EVX2) is a protein from Homo sapiens identified by UniProt accession Q03828, 476 residues long. MolForge cross-references it against 0 known binders and 330 disease associations.

Target properties

Protein name	Homeobox even-skipped homolog protein 2
UniProt accession	Q03828
Gene	EVX2
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (330)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
Alzheimer disease · score 0.34
multiple sclerosis · score 0.34
Parkinson disease · score 0.34
lysosomal storage disease · score 0.34
synpolydactyly type 1 · score 0.28
urate measurement · score 0.26
glomerular filtration rate · score 0.11
brachydactyly type A2 · score 0.09
familial digital arthropathy-brachydactyly · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03828-F1	alphafold	PREDICTED	54.10	—

Amino-acid sequence (476 residues)

MMERIRKEMI LMERGLHSPT AGKRFSNLSN SAGNAVLEAL ENSQHPARLS PRLPSAPLHS ALGELPAKGK FEIDTLFNLQ HTGSESTVSS EISSAAESRK KPGHYSEAAA EADMSSDVEV GCSALRSPGG LGAAQLKENN GKGYAESGSA AGTTTSASGS GLGSLHGGSG GSGGSAALGG SGSGADQVRR YRTAFTREQI ARLEKEFYRE NYVSRPRRCE LAAALNLPET TIKVWFQNRR MKDKRQRLAM SWPHPADPSF YTYMMTHAAA TGSLPYPFHS HVPLHYYPHV GVTAAAAAAA ASGAAAAASS PFATSIRPLD TFRALSHPYS RPELLCSFRH PGLYQAPAAA AGLNSAASAA AAAAAAAAAA SSAAAAGAPP SGGSAPCSCL SCHSSQSAAA AAAAAAAALG SRGGGGGGGG GGGGGGGGAG AGGGSDFGCS AAAPRSESGF LPYSAAVLSK TAVSPPDQRD EAPLTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards