Zinc finger protein 117 (ZNF117)

About Zinc finger protein 117

Zinc finger protein 117 (ZNF117) is a protein from Homo sapiens identified by UniProt accession Q03924, 483 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Zinc finger protein 117
UniProt accession	Q03924
Gene	ZNF117
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
retinitis pigmentosa · score 0.07
Leber congenital amaurosis · score 0.05
neoplasm · score 0.05
aniridia · score 0.05
Aniridia-intellectual disability syndrome · score 0.04
Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
congenital glaucoma · score 0.04
retinitis pigmentosa 71 · score 0.04
isolated optic nerve hypoplasia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03924-F1	alphafold	PREDICTED	76.01	—

Amino-acid sequence (483 residues)

MKRHEMVAKH LVMFYYFAQH LWPEQNIRDS FQKVTLRRYR KCGYENLQLR KGCKSVVECK QHKGDYSGLN QCLKTTLSKI FQCNKYVEVF HKISNSNRHK MRHTENKHFK CKECRKTFCM LSHLTQHKRI QTRVNFYKCE AYGRAFNWSS TLNKHKRIHT GEKPYKCKEC GKAFNQTSHL IRHKRIHTEE KPYKCEECGK AFNQSSTLTT HNIIHTGEIP YKCEKCVRAF NQASKLTEHK LIHTGEKRYE CEECGKAFNR SSKLTEHKYI HTGEKLYKCE ECGKAFNQSS TLTTHKRIHS GEKPYKCEEC GKAFKQFSNL TDHKKIHTGE KPYKCEECGK AFNQLSNLTR HKVIHTGEKP YKCGECGKAF NQSSALNTHK IIHTGENPHK CRESGKVFHL SSKLSTCKKI HTGEKLYKCE ECGKAFNRSS TLIGHKRIHT GEKPYKCEEC GKAFNQSSTL TTHKIIHTEE KQYKCDECGK AST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards