Heat shock factor protein 2 (HSF2)

About Heat shock factor protein 2

Heat shock factor protein 2 (HSF2) is a protein from Homo sapiens identified by UniProt accession Q03933, 536 residues long. MolForge cross-references it against 0 known binders and 237 disease associations.

Target properties

Protein name	Heat shock factor protein 2
UniProt accession	Q03933
Gene	HSF2
Organism	Homo sapiens
Length	536 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (237)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.47
leukocyte count · score 0.40
platelet crit · score 0.36
myeloid white cell count · score 0.34
neutrophil count · score 0.33
monocyte count · score 0.30
optic disc size measurement · score 0.27
mean platelet volume · score 0.24
neurofibrillary tangles measurement · score 0.24
response to bevacizumab · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q03933-F1	alphafold	PREDICTED	59.47	—

Amino-acid sequence (536 residues)

MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP KYFKHNNMAS FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ DDLLENIKRK VSSSKPEENK IRQEDLTKII SSAQKVQIKQ ETIESRLSEL KSENESLWKE VSELRAKHAQ QQQVIRKIVQ FIVTLVQNNQ LVSLKRKRPL LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE RISDDIIIYD VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND NINLLGKVEL LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM NPTDYINNTK SENKGLETTK NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL LAFLDGNPAS SVEQASTTAS SEVLSSVDKP IEVDELLDSS LDPEPTQSKL VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards