About AT-rich interactive domain-containing protein 5A
AT-rich interactive domain-containing protein 5A (ARID5A) is a protein
from Homo sapiens identified by UniProt accession
Q03989, 594 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | AT-rich interactive domain-containing protein 5A |
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| UniProt accession | Q03989 |
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| Gene | ARID5A |
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| Organism | Homo sapiens |
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| Length | 594 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.38
- eosinophil percentage of leukocytes · score 0.31
- sex hormone-binding globulin measurement · score 0.25
- eosinophil percentage of granulocytes · score 0.23
- lymphocyte:monocyte ratio · score 0.20
- sum of eosinophil and basophil counts · score 0.19
- BMI-adjusted hip circumference · score 0.16
- lymphocyte count · score 0.14
- pulse pressure measurement · score 0.11
- lymphocyte percentage of leukocytes · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03989-F1 | alphafold | PREDICTED | 54.38 | — |
Amino-acid sequence (594 residues)
MAAPVKGNRK QSTEGDALDP PASPKPAGKQ NGIQNPISLE DSPEAGGERE EEQEREEEQA FLVSLYKFMK ERHTPIERVP HLGFKQINLW KIYKAVEKLG AYELVTGRRL WKNVYDELGG SPGSTSAATC TRRHYERLVL PYVRHLKGED DKPLPTSKPR KQYKMAKENR GDDGATERPK KAKEERRMDQ MMPGKTKADA ADPAPLPSQE PPRNSTEQQG LASGSSVSFV GASGCPEAYK RLLSSFYCKG THGIMSPLAK KKLLAQVSKV EALQCQEEGC RHGAEPQASP AVHLPESPQS PKGLTENSRH RLTPQEGLQA PGGSLREEAQ AGPCPAAPIF KGCFYTHPTE VLKPVSQHPR DFFSRLKDGV LLGPPGKEGL SVKEPQLVWG GDANRPSAFH KGGSRKGILY PKPKACWVSP MAKVPAESPT LPPTFPSSPG LGSKRSLEEE GAAHSGKRLR AVSPFLKEAD AKKCGAKPAG SGLVSCLLGP ALGPVPPEAY RGTMLHCPLN FTGTPGPLKG QAALPFSPLV IPAFPAHFLA TAGPSPMAAG LMHFPPTSFD SALRHRLCPA SSAWHAPPVT TYAAPHFFHL NTKL
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