About Transcription factor p65
Transcription factor p65 (RELA) is a protein
from Homo sapiens identified by UniProt accession
Q04206, 551 residues long.
MolForge cross-references it against 0 known binders and
578 disease associations.
Target properties
| Protein name | Transcription factor p65 |
|---|
| UniProt accession | Q04206 |
|---|
| Gene | RELA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 551 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (578)
Diseases linked to this target (Open Targets).
- ulcer disease · score 0.60
- neurodegenerative disease · score 0.46
- inborn error of immunity · score 0.38
- multiple sclerosis · score 0.37
- severe acute respiratory syndrome · score 0.37
- Parkinson disease · score 0.37
- neuroinflammatory disorder · score 0.37
- Alzheimer disease · score 0.37
- lysosomal storage disease · score 0.37
- breast adenocarcinoma · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q04206-F1 | alphafold | PREDICTED | 72.19 | — |
Amino-acid sequence (551 residues)
MDELFPLIFP AEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG DYDLNAVRLC FQVTVRDPSG RPLRLPPVLS HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE KRKRTYETFK SIMKKSPFSG PTDPRPPPRR IAVPSRSSAS VPKPAPQPYP FTSSLSTINY DEFPTMVFPS GQISQASALA PAPPQVLPQA PAPAPAPAMV SALAQAPAPV PVLAPGPPQA VAPPAPKPTQ AGEGTLSEAL LQLQFDDEDL GALLGNSTDP AVFTDLASVD NSEFQQLLNQ GIPVAPHTTE PMLMEYPEAI TRLVTGAQRP PDPAPAPLGA PGLPNGLLSG DEDFSSIADM DFSALLSQIS S
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