UBX domain-containing protein 1 (UBXN1)

About UBX domain-containing protein 1

UBX domain-containing protein 1 (UBXN1) is a protein from Homo sapiens identified by UniProt accession Q04323, 297 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	UBX domain-containing protein 1
UniProt accession	Q04323
Gene	UBXN1
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

neoplasm · score 0.08
hepatocellular carcinoma · score 0.07
Adult-onset autosomal recessive sideroblastic anemia · score 0.05
blood protein measurement · score 0.05
hemoglobin E-beta-thalassemia syndrome · score 0.05
dehydrated hereditary stomatocytosis · score 0.05
microcytic anemia with liver iron overload · score 0.05
resting heart rate · score 0.04
hemoglobin D disease · score 0.04
mean corpuscular hemoglobin concentration · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q04323-F1	alphafold	PREDICTED	76.36	—

Amino-acid sequence (297 residues)

MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLGHIL GREPTSSEQG GLEGSGSAAG EGKPALSEEE RQEQTKRMLE LVAQKQRERE EREEREALER ERQRRRQGQE LSAARQRLQE DEMRRAAEER RREKAEELAA RQRVREKIER DKAERAKKYG GSVGSQPPPV APEPGPVPSS PSQEPPTKRE YDQCRIQVRL PDGTSLTQTF RAREQLAAVR LYVELHRGEE LGGGQDPVQL LSGFPRRAFS EADMERPLQE LGLVPSAVLI VAKKCPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards