Keratin, type I cytoskeletal 17 (KRT17)

About Keratin, type I cytoskeletal 17

Keratin, type I cytoskeletal 17 (KRT17) is a protein from Homo sapiens identified by UniProt accession Q04695, 432 residues long. MolForge cross-references it against 0 known binders and 449 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 17
UniProt accession	Q04695
Gene	KRT17
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (449)

Diseases linked to this target (Open Targets).

pachyonychia congenita 2 · score 0.80
sebocystomatosis · score 0.78
pachyonychia congenita · score 0.39
Anonychia · score 0.34
Abnormality of the skin · score 0.34
clear cell renal carcinoma · score 0.18
glioblastoma multiforme · score 0.18
genetic disorder · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q04695-F1	alphafold	PREDICTED	77.33	—

Amino-acid sequence (432 residues)

MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS TLGGSSYSSC YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY QRQAPGPARD YSQYYRTIEE LQNKILTATV DNANILLQID NARLAADDFR TKFETEQALR LSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK EPVTTRQVRT IVEEVQDGKV ISSREQVHQT TR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards