About Acetylcholine receptor subunit epsilon
Acetylcholine receptor subunit epsilon (CHRNE) is a protein
from Homo sapiens identified by UniProt accession
Q04844, 493 residues long.
MolForge cross-references it against 0 known binders and
168 disease associations.
Target properties
| Protein name | Acetylcholine receptor subunit epsilon |
|---|
| UniProt accession | Q04844 |
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| Gene | CHRNE |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (168)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.83
- Postsynaptic congenital myasthenic syndromes · score 0.73
- post-operative sign or symptom · score 0.58
- Bernard-Soulier syndrome · score 0.56
- congenital myasthenic syndrome · score 0.56
- pain · score 0.55
- acute respiratory distress syndrome · score 0.53
- platelet-type von Willebrand disease · score 0.53
- Abnormality of the musculature · score 0.51
- severe acute respiratory syndrome · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q04844-F1 | alphafold | PREDICTED | 80.72 | — |
Amino-acid sequence (493 residues)
MARAPLGVLL LLGLLGRGVG KNEELRLYHH LFNNYDPGSR PVREPEDTVT ISLKVTLTNL ISLNEKEETL TTSVWIGIDW QDYRLNYSKD DFGGIETLRV PSELVWLPEI VLENNIDGQF GVAYDANVLV YEGGSVTWLP PAIYRSVCAV EVTYFPFDWQ NCSLIFRSQT YNAEEVEFTF AVDNDGKTIN KIDIDTEAYT ENGEWAIDFC PGVIRRHHGG ATDGPGETDV IYSLIIRRKP LFYVINIIVP CVLISGLVLL AYFLPAQAGG QKCTVSINVL LAQTVFLFLI AQKIPETSLS VPLLGRFLIF VMVVATLIVM NCVIVLNVSQ RTPTTHAMSP RLRHVLLELL PRLLGSPPPP EAPRAASPPR RASSVGLLLR AEELILKKPR SELVFEGQRH RQGTWTAAFC QSLGAAAPEV RCCVDAVNFV AESTRDQEAT GEEVSDWVRM GNALDNICFW AALVLFSVGS SLIFLGAYFN RVPDLPYAPC IQP
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