About 14-3-3 protein eta
14-3-3 protein eta (YWHAH) is a protein
from Homo sapiens identified by UniProt accession
Q04917, 246 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | 14-3-3 protein eta |
|---|
| UniProt accession | Q04917 |
|---|
| Gene | YWHAH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 246 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- monocyte count · score 0.36
- glioblastoma multiforme · score 0.29
- HbA1c measurement · score 0.28
- breast adenocarcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.27
- gastric adenocarcinoma · score 0.26
- monocyte percentage of leukocytes · score 0.25
- sex hormone-binding globulin measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q04917-F1 | alphafold | PREDICTED | 95.27 | — |
Amino-acid sequence (246 residues)
MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
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