Proteolipid protein 2 (PLP2)

About Proteolipid protein 2

Proteolipid protein 2 (PLP2) is a protein from Homo sapiens identified by UniProt accession Q04941, 152 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Proteolipid protein 2
UniProt accession	Q04941
Gene	PLP2
Organism	Homo sapiens
Length	152 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
neoplasm · score 0.09
glioblastoma multiforme · score 0.09
Miyoshi myopathy · score 0.07
nonpapillary renal cell carcinoma · score 0.07
esophageal squamous cell carcinoma · score 0.05
melanoma · score 0.03
acute myeloid leukemia · score 0.03
glioblastoma · score 0.02
cancer · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q04941-F1	alphafold	PREDICTED	78.75	—

Amino-acid sequence (152 residues)

MADSERLSAP GCWAACTNFS RTRKGILLFA EIILCLVILI CFSASTPGYS SLSVIEMILA AIFFVVYMCD LHTKIPFINW PWSDFFRTLI AAILYLITSI VVLVERGNHS KIVAGVLGLI ATCLFGYDAY VTFPVRQPRH TAAPTDPADG PV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards