Cleavage stimulation factor subunit 1 (CSTF1)

About Cleavage stimulation factor subunit 1

Cleavage stimulation factor subunit 1 (CSTF1) is a protein from Homo sapiens identified by UniProt accession Q05048, 431 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Cleavage stimulation factor subunit 1
UniProt accession	Q05048
Gene	CSTF1
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
mean corpuscular volume · score 0.06
lean body mass · score 0.05
mean corpuscular hemoglobin concentration · score 0.04
body height · score 0.04
mean corpuscular hemoglobin · score 0.04
reticulocyte count · score 0.03
appendicular lean mass · score 0.03
mean reticulocyte volume · score 0.03
reticulocyte measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05048-F1	alphafold	PREDICTED	90.43	—

Amino-acid sequence (431 residues)

MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NSSANMYVTG SKDGCIKLWD GVSNRCITTF EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV FNHTEDYVLL PDERTISLCC WDSRTAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR ARFWYRRSTT D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards