Sex-determining region Y protein (SRY)

About Sex-determining region Y protein

Sex-determining region Y protein (SRY) is a protein from Homo sapiens identified by UniProt accession Q05066, 204 residues long. MolForge cross-references it against 0 known binders and 277 disease associations.

Target properties

Protein name	Sex-determining region Y protein
UniProt accession	Q05066
Gene	SRY
Organism	Homo sapiens
Length	204 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (277)

Diseases linked to this target (Open Targets).

46,XY sex reversal 1 · score 0.80
46,XX sex reversal 1 · score 0.63
46,XY complete gonadal dysgenesis · score 0.40
46,XY partial gonadal dysgenesis · score 0.39
46,XX testicular disorder of sex development · score 0.39
46,XX ovotesticular disorder of sex development · score 0.39
46,XY disorder of sex development · score 0.27
46,XY disorder of sex development due to isolated 17,20 lyase deficiency · score 0.09
Testicular regression syndrome · score 0.08
precocious puberty, central, 2 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05066-F1	alphafold	PREDICTED	67.62	—

Amino-acid sequence (204 residues)

MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE NSKGNVQDRV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRYSH WTKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards