Islet cell autoantigen 1 (ICA1)

About Islet cell autoantigen 1

Islet cell autoantigen 1 (ICA1) is a protein from Homo sapiens identified by UniProt accession Q05084, 483 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Islet cell autoantigen 1
UniProt accession	Q05084
Gene	ICA1
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.32
protein measurement · score 0.32
serum gamma-glutamyl transferase measurement · score 0.30
self reported educational attainment · score 0.27
intraocular pressure measurement · score 0.22
schizophrenia · score 0.05
intelligence · score 0.05
autoimmune disease · score 0.04
hepatorenocardiac degenerative fibrosis · score 0.04
kidney disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05084-F1	alphafold	PREDICTED	69.81	—

Amino-acid sequence (483 residues)

MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL LNA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards