About Glutamate decarboxylase 2
Glutamate decarboxylase 2 (GAD2) is a protein
from Homo sapiens identified by UniProt accession
Q05329, 585 residues long.
MolForge cross-references it against 0 known binders and
417 disease associations.
Target properties
| Protein name | Glutamate decarboxylase 2 |
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| UniProt accession | Q05329 |
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| Gene | GAD2 |
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| Organism | Homo sapiens |
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| Length | 585 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (417)
Diseases linked to this target (Open Targets).
- glucose measurement · score 0.35
- hemoglobin A1 measurement · score 0.32
- arterial stiffness measurement · score 0.29
- adolescent idiopathic scoliosis · score 0.26
- thyroid gland adenocarcinoma · score 0.23
- neuroinflammatory disorder · score 0.19
- cutaneous melanoma · score 0.13
- diabetes mellitus · score 0.10
- type 1 diabetes mellitus · score 0.10
- Obesity · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05329-F1 | alphafold | PREDICTED | 89.78 | — |
Amino-acid sequence (585 residues)
MASPGSGFWS FGSEDGSGDS ENPGTARAWC QVAQKFTGGI GNKLCALLYG DAEKPAESGG SQPPRAAARK AACACDQKPC SCSKVDVNYA FLHATDLLPA CDGERPTLAF LQDVMNILLQ YVVKSFDRST KVIDFHYPNE LLQEYNWELA DQPQNLEEIL MHCQTTLKYA IKTGHPRYFN QLSTGLDMVG LAADWLTSTA NTNMFTYEIA PVFVLLEYVT LKKMREIIGW PGGSGDGIFS PGGAISNMYA MMIARFKMFP EVKEKGMAAL PRLIAFTSEH SHFSLKKGAA ALGIGTDSVI LIKCDERGKM IPSDLERRIL EAKQKGFVPF LVSATAGTTV YGAFDPLLAV ADICKKYKIW MHVDAAWGGG LLMSRKHKWK LSGVERANSV TWNPHKMMGV PLQCSALLVR EEGLMQNCNQ MHASYLFQQD KHYDLSYDTG DKALQCGRHV DVFKLWLMWR AKGTTGFEAH VDKCLELAEY LYNIIKNREG YEMVFDGKPQ HTNVCFWYIP PSLRTLEDNE ERMSRLSKVA PVIKARMMEY GTTMVSYQPL GDKVNFFRMV ISNPAATHQD IDFLIEEIER LGQDL
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