Protein kinase C zeta type (PRKCZ)

About Protein kinase C zeta type

Protein kinase C zeta type (PRKCZ) is a protein from Homo sapiens identified by UniProt accession Q05513, 592 residues long. MolForge cross-references it against 0 known binders and 279 disease associations.

Target properties

Protein name	Protein kinase C zeta type
UniProt accession	Q05513
Gene	PRKCZ
Organism	Homo sapiens
Length	592 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (279)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.50
mast-cell leukemia · score 0.47
neoplasm · score 0.40
neurodegenerative disease · score 0.39
systemic mastocytosis · score 0.39
Mastocytosis · score 0.37
Alzheimer disease · score 0.30
Parkinson disease · score 0.30
multiple sclerosis · score 0.30
lysosomal storage disease · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q05513-F1	alphafold	PREDICTED	78.95	—

Amino-acid sequence (592 residues)

MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL HQQHPLTLKW VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP EQPGLPCPGE DKSIYRRGAR RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHGLVPLTC RKHMDSVMPS QEPPVDDKNE DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF LSVKASHVLK GFLNKDPKER LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT DDYGLDNFDT QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards